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 estrogens (oestrogens)

Estrogens or Oestrogens, are a group of compounds named for their importance in both menstrual and estrous reproductive cycles. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal. The name comes from the Greek οἶστρος (oistros), literally meaning "gadfly" but figuratively sexual passion or desire, and the suffix -gen, meaning "producer of".


Estrogens are synthesized in all vertebrates as well as some insects. Their presence in both vertebrates and insects suggests that estrogenic sex hormones have an ancient evolutionary history.


Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for trans women.


Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors which in turn modulate the expression of many genes. Additionally, estrogens have been shown to activate a G protein-coupled receptor, GPR30.

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updated Tue. February 5, 2019

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Objectives: Depressive symptoms are common during pregnancy and after childbirth. Estrogen levels fluctuate greatly during the course of pregnancy and may contribute to mood instability. The first aim of this case–control study was to investigate whether variants in the two estrogen receptor genes might ...
New data are suggesting there is phenotypic and molecular interplay between estrogen receptor (ER) alpha and glucocorticoid receptor (GR) in endometrial cancer, which may be affecting outcomes. In an article published in the journal Cell Reports, researchers reported these two receptors are ...

Welcome to life without estrogen. "Preclinical data has shown that either surgical menopause or declines in estrogen accelerates fat accumulation, primarily visceral or abdominal fat," said Dr. JoAnn Pinkerton, executive director of the North American Menopause Society. "Changes over time in how women ...
Testosterone therapy is not associated with a rise in estrogen levels among transgender men, according to a new study led by Boston Medical Center (BMC). In fact, the researchers observed an initial decline in estrogen levels, which later stabilized and remained within the normal range during the study's ...
The present guidelines for the treatment of transgender men using testosterone therapy state that there might be a need to include estrogen-lowering strategies such as the removal of the uterus or ovaries. But a new study led by Boston Medical Center (BMC) suggests that testosterone therapy is not linked ...
CHICAGO (AP) - In a study of women with menopause-related sexual discomfort, gels worked as well as prescription hormone tablets at reducing symptoms. The researchers say the results suggest low-cost, over-the-counter moisturizers might be the best option. Most women reported some relief from their ...

Soy contains very concentrated amounts of isoflavones—a chemical compound that acts very similarly to estrogen in the human body due to its similar chemical structure. So, while soy may not raise estrogen levels directly, it effectively provides an additional influx of estrogen-like compounds that can ...
Researchers at the NIEHS, including Kenneth Korach, Ph.D., a co-investigator for the new study, previously found laboratory evidence that lavender and tea tree oil have estrogenic (estrogen-like) properties and anti-androgenic (testosterone inhibiting-like) activities, meaning they compete or hinder the ...
"Female athletes with exercise-induced menstrual dysfunction (associated with low estrogen levels) often have disordered eating behaviour, which may impact their reproductive and bone health," lead researcher Madhusmita Misra of Massachusetts General Hospital in Boston, Mass told ANI.
In young female athletes with oligo-amenorrhea, estrogen replacement therapy may improve disordered eating behavior and psychopathology by normalizing estrogen levels, according to an abstract presented at ENDO 2018: The Endocrine Society Annual Meeting, held March 17-20 in Chicago, Illinois.1.
Giving one year of estrogen replacement to female athletes with exercise-induced menstrual irregularities improves drive for thinness, body dissatisfaction and uncontrolled eating, a new study finds. The research results will be presented Saturday, March 17, at ENDO 2018, the annual scientific meeting of ...
CHICAGO — Young female athletes with normal weight and no or irregular menstrual periods reported fewer disordered eating behaviors, diminished drive for thinness and less body dissatisfaction after receiving 12 months of estrogen therapy, according to findings of a cross-sectional study and a ...
Acupuncture is one of many alternatives to estrogen therapy for women going through menopause. (KABC) ... While healthy women - who aren't at high risk for heart disease or cancer - may be able to take estrogen therapy safely, there are non-HRT medications she recommends for hot flashes. One is a ...
Two University of Houston researchers, working to find cancer cures, received grants from the Cancer Prevention & Research Institute of Texas (CPRIT), the organization that funds groundbreaking cancer research and prevention programs in the state. CPRIT awarded $1,173,420 to Navin Varadarajan, ...
Nerve cells in cognitive regions of the brain that are earliest affected by Alzheimer's disease depend on estrogens for proper functioning. The precipitous loss of estrogens at menopause leaves these cells more vulnerable to the detrimental effects of the disease. Although estrogen treatment can reverse ...
By the time a woman is in her 50's, there are very few eggs left in the ovaries, and consequently, there are significantly decreased or even undetectable levels of estrogens and progesterone in the body. After the menopause (defined as 12 consecutive months with no menstrual period), when there are no ...
Birth control pills together with the very lowest volume of estrogen, that ... and is also a compounding pill containing estrogens and progestins.

Hot flashes, night sweats, weight gain and more, are all uncomfortable symptoms of menopause. For the past decade and a half, many women ...
BOSTON, Mass. (Ivanhoe Newswire) -- In the 1990's estrogen was the most prescribed medicine in the United States. But in 2002, a study ...
But in 2002, a study came out saying estrogen hormones caused an increased ... We learn more about the estrogen window in Healthy Living.
Gynecomastia occurs in adolescence due to a relative imbalance of estrogen and testosterone. The relatively elevated levels of estrogen ...
As men age, their estrogen levels rise and their testosterone drops as the ... of detoxification enzymes that eliminate environmental estrogens.
Researchers at the Icahn School of Medicine at Mount Sinai have identified a protein that can be targeted to suppress growth of a common type ...
One researcher says it's time to rethink hormone therapy during a specific period of time during menopause, more on the estrogen window.
In the 1990s, estrogen was the most prescribed medicine in the United States until a study came out in 2002 saying estrogen hormones caused ...
Estrogen was the most prescribed medicine in the U.S. in the 90s, but then a study said estrogen caused an increased health risk for women.
Maria J. Torres, right, prepares equipment in the lab as Darrell Neufer, director of the East Carolina Diabetes and Obesity Institute, observes.
Endocrine disruptors became a trend in the 1990s so anything with the word estrogen in it was linked to changes in humans. Since hops ...
"Our study suggests that estrogen treatment after menopause protects the memory that is needed for short-term cognitive tasks from the effects ...
The cast of The Addams Family, which continues this week at the Melon Patch Theatre, 311 N. 13th St. in Leesburg and plays until Nov. 12.
Increased serum oestrogen levels because of hormone ... and cardiovascular events in participants who used vaginal estrogen in the Women's ...
The reason the removal of ovaries helped breast cancer patients was because ovaries are major sources for producing the hormone, estrogen.
She was given a combination of medications, including one that blocks estrogen and another from a new class of what's known as "CDK ...
In Jenni's case, when estrogen gets out of balance, other hormones like ... Studies show environmental estrogens can mimic, block, or cancel ...
This is because, they contain a high amount of phytoestrogen, a plant derived chemical that is similar to the female sex hormone, oestrogen.
“This report provides long-term results of the largest study to date addressing the safety of pregnancy according to oestrogen-receptor status,” ...
These drugs work by attaching to estrogen receptors in breast cells, blocking estrogen's ability to cause cell mutations that lead to cancer.
Laurel resident Sheila Hennis said she has no family history of breast cancer, but just three months ago, she was diagnosed with a form of ...
Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, ...
The reason: estrogen, which can stimulate cell overgrowth and breast ... "Among women who exercise, the ratio of 'good' estrogens to 'bad' ...
All breast cancers are either estrogen receptor-positive or estrogen receptor-negative. The tumors in estrogen receptor, or ER, negative breast ...
"Oestrogen affects our skin in many ways, like helping maintain skin moisture and stimulating the production of collagen - the protein that keeps ...
When you say the word “estrogen” that's actually three compounds: ... (termed phytoestrogens) which kicks off dangerous estrogens from your ...
All breast cancers are either estrogen receptor-positive or estrogen receptor-negative. The tumors in estrogen receptor, or ER, negative breast ...
Cancer risk for post-menopausal women includes breast and endometrial cancers and are related to estrogen levels explained Dr. Shauer.
The one-day event on Oct. 28 will mark Breast Cancer Awareness Month by exploring the relationship between sex hormones and ...
PHILADELPHIA — Combination estrogen and progestin hormone therapy can serve as a “necessary evil” for endometrial protection, but its use ...
I'll Co-host an estrogen tour with you any day @jimmykimmel because to be clear: takes a REAL man to cry in public. ❤ pic.twitter.com/ ...
Menopause leads to the cessation of ovarian estrogen production concurrent to the deterioration of muscle function. After menopause, the risk ...
Modern medicine offers several primary ways to treat breast cancer, including surgery, radiation, chemotherapy and anti-estrogen treatments.


 

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