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 enzymes

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updated Mon. April 2, 2018

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Russian biologists from Moscow State University have recently published a study devoted to the structure of part of the telomerase enzyme. One of the authors noted that the study will help develop treatments that can both stimulate or inhibit the enzyme's activity. Telomerase is required for the ... Scientists
WASHINGTON, April 2 (Xinhua) -- American and Chinese scientists have identified how a multi-functional enzyme works to fight diseases including HIV infection and autoimmune disorders. The study, published on Monday in the journal Proceedings of the National Academy of Sciences, has detailed ...

Eddie the Enzyme is ready to break down food and take on the competition in pancreatic enzyme products. The spokescharacter, created by Allergan, works in "interdigestive space" with a friendly message about the need for prescription enzymes for people with exocrine pancreative insufficiency (EPI).
The new study shows that the synthetic compound is capable of inhibiting the activities of several DNA-processing enzymes, including the 'integrase' used by the Human Immunodeficiency Virus (HIV) to insert its genome into that of its host cell. The successful demonstration of the efficacy of the ... chemistry
For more than eight decades, National Enzyme Company has been working in the dietary supplement business. Dr. Edward Howell started NEC in 1932 with a vision of replacing the enzymes lost in cooking and he created enzyme supplements, according to the company's website. His ...
"Even if we know exactly what an enzyme does," Li says, "we still don't have a sense for how much of that protein the cell will make. Thinking about biochemical pathways is even more complicated. If we gave biochemists three enzymes in a pathway that, for example, break down sugar into energy, ...

Crystal structure of the host enzyme, Acyloxyacyl Hydrolase (AOAH), in complex with lipopolysaccharide (LPS) shown in grey sticks, which is a potent bacterial toxin. The figure shows one of the six fatty acid chains of LPS swung out and …more. Biochemists from McGill University are getting a good look ...
Protein Hydrolysis Enzymes Market Report covers the comprehensive market, vendor landscape, present scenario, and the growth prospects of the Protein Hydrolysis Enzymes for 2017-2022. report, consists of various factors such as definitions, applications, and classifications. Global Sales Volume, Sales ...
... researchers at UC Davis' Siegel Lab are conducting a series of lab experiments on native wheat enzymes in several varieties of wheat to determine their activity and sensitivity to heat. The study will examine a series of mutations to find one that could be injected into the enzyme to make it heat stable.
Researchers in Hong Kong may have identified a factor behind the rise of the superbugs after discovering a type of enzyme that can break down antibiotics. The team from the Hong Kong University of Science and Technology said the find could help pharmaceutical companies develop more effective drugs ...
Scientists at UC Berkeley have created a protein mat that can absorb chemical pollution, providing a breakthrough in scientific research that could potentially be applied to war zones and contaminated sites. The applications of this groundbreaking discovery include degrading pollutants such as pesticides ...
Sitting inside the Schwann cells, an enzyme known as fatty acid synthase (FASN) acts as a central "switch" in the process of synthesising lipids. The team found that this enzyme is essential for the correct composition of lipids in the insulating layers, for the cells to start myelination, and for the healthy growth ...
Unactivated alkenes have been transformed into four stereoisomers of cyclopropane by a group of enzymes – the first example of a biocatalytic reaction performed by haem proteins that does not occur in nature. The set of biocatalysts could serve as starting points for 'green' synthesis of cyclopropanated ...
But the exact influence of the molecules to the enzyme is not yet fully understood. For that reason, Ben Bdira studied these different molecules to produce a molecule that could be used against Gaucher's disease. In the future, he hopes this knowledge can be used to reduce the effects of metabolic diseases ...
... the mechanism appears to differ from that of the bacterial version of the enzyme, suggesting that it could be possible to design antibiotics that selectively block the bacterial enzyme. "People have been trying to figure out whether there is something different enough that you could inhibit bacterial enzymes ...
The research findings may prove useful in the future for developing new antibiotics and in industrial contexts where it is important to be able to switch enzymes on and off in the production of chemicals. "This function could potentially be used to stick other unrelated proteins together to prevent them from ...
Instead, they are first synthesized with chains of amino acids that block their activity until they are removed by enzymes called "proprotein convertases" (PCs). This family of enzymes plays significant but very different roles in various cancers, and regulating the activity of PCs could help develop cancer ...

"By considering these key enzymes and figuring out what are the differences and similarities, we can see if there's anything in the bacterial enzyme that could be targeted with small-molecule drugs." Drennan is one of the senior authors of the study, which appears in the Feb. 20 issue of the journal eLife.
“By considering these key enzymes and figuring out what are the differences and similarities, we can see if there's anything in the bacterial enzyme that could be targeted with small-molecule drugs.” Drennan is one of the senior authors of the study, which appears in the Feb. 20 issue of the journal eLife.
Enzymes are proteins that speed up or catalyze a reaction in living organisms. Bacteria can produce enzymes that make them resistant to antibiotics. Specifically, the TEM beta-lactamase enzyme enables bacteria to develop a resistance to beta-lactam antibiotics, such as penicillin and cephalosporins.
Enzymes are proteins that speed up or catalyze a reaction in living organisms. Bacteria can produce enzymes that make them resistant to antibiotics. Specifically, the TEM beta-lactamase enzyme enables bacteria to develop a resistance to beta-lactam antibiotics, such as penicillin and cephalosporins.
Knocking back an enzyme swept mouse brains clean of protein globs that are a sign of Alzheimer's disease. Reducing the enzyme is known to keep these nerve-damaging plaques from forming. But the disappearance of existing plaques was unexpected, researchers report online February 14 in the ...
While he notes that "[t]his is probably not the only pathway accounting for energy expenditure in fasting or obesity," he adds, "[T]his information provides new insight into how we might develop drugs that inhibit TBK1 or other enzymes involved in metabolism." Still, the researchers note that taking special ...
Under optimum conditions, enzymes can work quickly -- up to 20,000 times per second -- to speed up the chemical process of fermentation. Most of the enzymes in forage inoculants break down complex materials into simpler materials. Each type of enzyme contributes differently to the ensiling process.
With some engineering in the lab, a quartet of iron-containing heme proteins from microbes can convert inert alkenes into each possible stereoisomer of cyclopropanes, which are valuable motifs in medicinally active compounds (ACS Cent. Sci. 2018, DOI: 10.1021/acscentsci.7b00548). Previous ...
In both nature and industrial processes, enzymes from this family are among the most significant enzymes for breaking down cellulose. A projected 2,000-ton-per-day cellulosic ethanol plant could potentially use up to 5,000 tons of enzyme per year, and half of that enzyme cocktail could be from this ...
In both nature and industrial processes, enzymes from this family are among the most significant enzymes for breaking down cellulose. A projected 2,000-ton-per-day cellulosic ethanol plant could potentially use up to 5,000 tons of enzyme per year, and half of that enzyme cocktail could be from this ...
Moreover, new information about the hydrogen-bonding networks that make up the active site within hCA II could be used to develop novel drugs for cancer treatment given that the family of hCA enzymes contains similar proteins, such as hCA IX and XII, which are, for instance, closely associated with ...
Scientists have seen the enzyme as an ideal target for drugs. Human cells do not seem to contain any similar enzymes, so it should be possible to design a drug which inactivates HIV integrase but is not toxic to human cells. But before designing a drug which targets a specific enzyme, researchers must ...
An experimental treatment completely reversed Alzheimer's disease in mice by reducing the levels of a single enzyme in the animals' brains. The results further bolster the theory that amyloid plaques are at the root of this mysterious brain disease, and that addressing these plaques could lead to an ...
The research, published in the journal Cell, focused on a member of a group of enzymes called flap endonucleases, which are essential to the life of a cell. The findings show new, clearly defined crystal structures of the enzyme FEN1 in action — demonstrating it functions in a way opposite to accepted ...
"If we can understand binding at the atomic level, we can redesign drugs and turn them into stronger and more selective 'magnets' that will be attracted to cancer-associated enzymes. Such drugs would be much more effective at killing cancer cells while leaving healthy cells unhurt, which significantly ...
Determining the structure of OST was not easy: to start with, Jilliane Eyring, the third lead author of the report, modified the yeast cells so that the enzyme could be targeted and purified. Wild first had to extract the enzyme, which is embedded in a membrane in the cell, from large quantities of these yeast ...
One difficulty in understanding how de novo DNA methylation works is that the structures of these enzymes are not known. The UC Riverside-led team has now solved the crystal structure for substrate-bound DNMT3A. This breakthrough reveals how the enzyme recognizes and methylates its substrates ...
The dairy enzymes market is estimated at USD 519.4 million in 2017, and projected to grow at a CAGR of 7.18%, to reach USD 734.6 million by 2022. ... Microbial rennet is a coagulating agent and considered vegetarian-friendly as the enzyme produced by the microorganism is not derived from animals
While he notes that "[t]his is probably not the only pathway accounting for energy expenditure in fasting or obesity," he adds, "[T]his information provides new insight into how we might develop drugs that inhibit TBK1 or other enzymes involved in metabolism." Still, the researchers note that taking special ...
Sometimes the body doesn't make enough digestive enzymes. This can slow the digestion process and lead to uncomfortable symptoms. For example, if you don't make enough of the enzyme lactase, you'll have a hard time digesting lactose — the sugar in milk and milk-based products. "If you don't have ...
Dr. Wolfgang Hess from the University of Freiburg have now identified an enzyme, a special pair of RNA scissors, which is involved in CRISPR/Cas systems and the correct regulation of gene expression -- in other words, in reading genes and translating their information into proteins. The researchers have ...
The deadly Ebola virus incorporates a cellular enzyme into its virus particles, facilitating the infection to the target cells, according to new research published in the journal PLOS Pathogens. When this enzyme Xkr8 is activated, it flips a phospholipid called phosphatidylserine (PS) from the inner layer of the ...
“ADM is getting into enzymes,” she told FeedNavigator. “The first enzyme that we're focusing on is an NSP enzyme – what that means is when we include higher levels of fiber [in feeds] there are portions of those ingredients that the pig or chicken cannot utilize well, so this is just like phytase, this is an ...
"Now we've worked out how to crystallise these enzymes and how they work, we're looking how to use bacteria to cheaply create highly efficient enzymes." Dr. Mylne led the team of Australian and US scientists that revealed the enzyme process through the Australian Research Council-supported study ...
Ann Donnelly was utterly confused the first time she examined her protein. On all counts, it behaved like an enzyme—a protein catalyst that speeds up biological reactions in cells. One could argue that enzymes, sculpted by eons of evolution, make life possible. There was just one problem: her protein ...
Our results delineate a minimum set of enzymes required to make chlorophyll and establish a platform for engineering photosynthesis in a heterotrophic model organism. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
Now, a team of Japanese researchers led by Hiroshi Inoue from Kanazawa University, Ishikawa, and collaborators from the National Centre for Global Health and Medicine, Tokyo, have identified a sirtuin enzyme (Sirt2) as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting ...
The enzyme appears to drive the conversion of normal colon tissue into cancer by attaching sugar molecules, or glycans, to certain proteins in the cell. ... Hans Wandall's team at the University of Copenhagen studied a group of 20 enzymes that initiate the first step in a particular kind of glycan modification, ...
Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ability to turn genes involved in lipid metabolism on or off. The study is being published in the journal Cell Reports.
Supplementing certain digestive enzymes can be helpful for digestion problems. However, since there are so many enzymes that play a role in digestion, and so many available products with varying degrees of purity, reasonable claims, etc., it is not easy for a consumer to try to choose their own enzyme ...
... enzymes that produce them have barely changed over many millions of years of evolution. For example, the ceramide synthase of the Drosophila fruit fly is very similar to that of humans. However, in contrast to the insect which is only a few millimeters in size, we have six different variants of the enzyme.
An international group of researchers demonstrated that the enzyme EXD2 has a key role in the production of mitochondrial protein. The study, “EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation,” was published in the journal Nature Cell Biology.
ADM's initial focus for the upcoming enzyme work will be on production for monogastric animals, he said. “ADM has vast experience and expertise in the area of feed and feed ingredients – both on the macro and the micro level,” he said of the focus for the work. “We are able to approach the enzymes ...


 

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